Targeting Macrophage Migration Inhibitory Factor in Acute Pancreatitis and Pancreatic Cancer

Macrophage Migration Inhibitory Factor

Gene polymorphisms of the macrophage migration inhibitory factor and acute pancreatitis.

CONTEXT Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is released by macrophages and lymphocytes and plays an important pathogenetic role in acute pancreatitis. It is present in large amounts in the serum and ascitic fluid in rats with experimental pancreatitis and its levels are elevated in humans with pancreatitis. Polymorphisms associated with inflammatory j...

Macrophage Migration Inhibitory Factor in Acute Adipose Tissue Inflammation

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine and has been implicated in inflammatory diseases. However, little is known about the regulation of MIF in adipose tissue and its impact on wound healing. The aim of this study was to investigate MIF expression in inflamed adipose and determine its role in inflammatory cell recruitment and wound healing. Adipose tissue was ha...

Correlation between urine macrophage migration inhibitory factor (MIF)/creatinine ratio and time after kidney transplantation

 Abstract  Background: Despite the long-standing association of macrophage migration inhibitory  factor (MIF) with delayed-type hypersensitivity response, the potential role  of MIF in chronic allograft nephropathy is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of  chronic allograft nephropathy suggests that MIF may be an ...

Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia.

Acute pancreatitis accompanied by a subsequent infectious attack can often lead to multisystem organ dysfunction, including acute lung injury (ALI), but the molecular mechanisms are poorly defined. In this study, we explored the role of the priming insult by induction of cerulein pancreatitis, which was followed by the second attack due to endotoxemia, in the development of ALI in mice. Experim...